Cortactin(Phospho Tyr421) Polyclonal Antibody, 50ul Cellular Cultivation & Health Management The protein directly interacts with

The protein directly interacts with several components of the NPC

thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1

Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2)

migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance

Cortactin(Phospho Tyr421) Polyclonal Antibody, 50ul Cellular Cultivation & Health Management The protein directly interacts withThis gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase