BubR1 Polyclonal Antibody, 100ul 3D Culture Mutations at this locus have

Mutations at this locus have been associated with lethal congenital contractural syndrome

and proposed to regulate cell-cycle progression during spermatogenesis

not all variants have been described

Two alternatively spliced transcripts encoding the same isoform have been reported

BubR1 Polyclonal Antibody, 100ul 3D Culture Mutations at this locus haveBUB1B encodes a kinase involved in spindle checkpoint function. The protein (BUB1 mitotic checkpoint serine threonine kinase B)has been localized to the kinetochore and plays a role in the inhibition of the anaphase promoting complex cyclosome (APC C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.