CRYL1 Rabbit Polyclonal Antibody, 100ul Sampling Tubes Two alternatively spliced variants encoding

Two alternatively spliced variants encoding distinct isoforms have been described

The encoded protein is a substrate for cGMP-dependent protein kinase

Several transcript variants have been found for this gene

Mutations in this gene cause Alexander disease

CRYL1 Rabbit Polyclonal Antibody, 100ul Sampling Tubes Two alternatively spliced variants encodingThe uronate cycle functions as an alternative glucose metabolic pathway accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L gulonate into dehydro L gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye.