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This technology has been widely applied in fundamental research

Single nucleotide polymorphisms in REL are associated with susceptibility to ulcerative colitis and rheumatoid arthritis

In addition to its role in regulating the later stages of terminal differentiation of keratinocytes

Ref-1 Polyclonal Antibody, 50ul[BT-AP07734] Sample Library Tubes Don't let RNases destroy yourApurinic apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. APEX1 encodes the major AP endonuclease in human cells.