IRF-3 Polyclonal Antibody, 50ul[BT-AP04629] Immunoassays developmental stage:Levels of expression in

developmental stage:Levels of expression in fibroblasts decrease heterogeneously during cellular aging

Proposed to be a ATP-dependent chromatin remodeling protein

The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases

This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling

IRF-3 Polyclonal Antibody, 50ul[BT-AP04629] Immunoassays developmental stage:Levels of expression inIRF3 encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed