PDCD5 Polyclonal Antibody, 50ul Purification Belongs to the AP-2 family

Belongs to the AP-2 family

Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions

Unlike factor VIII| this gene is transcribed abundantly in a wide variety of cell types

The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus

PDCD5 Polyclonal Antibody, 50ul Purification Belongs to the AP-2 familyThis gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12