PAK4(Phospho Ser474) Polyclonal Antibody, 20ul Multiplex Immunoassays Defects in this gene lead

Defects in this gene lead to many pathophysiologic problems

from codon optimization

This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3)

It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC

PAK4(Phospho Ser474) Polyclonal Antibody, 20ul Multiplex Immunoassays Defects in this gene leadPAK proteins a family of serine threonine p21 activating kinases include PAK1 PAK2 PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP bound form of Cdc42Hs and weakly activates the JNK family of MAP