MSH2 Monoclonal Antibody, 50ul Cellular Cultivation & Health Management Mitogen-activated protein kinase kinase kinase
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MSH2 Monoclonal Antibody, 50ul Cellular Cultivation & Health Management Mitogen-activated protein kinase kinase kinaseThis locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
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