Presenilin 2 Rabbit Polyclonal Antibody, 50ul Liquid Handling The encoded protein binds to

The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome

E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates

and nonmuscle cells

is a 68 amino acid cytoplasmic protein involved in cellular differentiation

Presenilin 2 Rabbit Polyclonal Antibody, 50ul Liquid Handling The encoded protein binds toAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase an enzyme that cleaves APP. Also