Raf-1(Phospho Thr269) Polyclonal Antibody, 100ul Mammalian Expression Two pseudogenes of this gene

Two pseudogenes of this gene have been identified on chromosomes 10 and 4

During interphase

Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders

This gene was identified by the interaction of its gene product with Grap2

Raf-1(Phospho Thr269) Polyclonal Antibody, 100ul Mammalian Expression Two pseudogenes of this geneThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.