TH Polyclonal Antibody, 50ul[BT-AP08988] Protein Analysis Members of the F-box protein

Members of the F-box protein family| such as FBXL18| are characterized by an approximately 40-amino acid F-box motif

an essential component of combination chemotherapy regimens for cancer

It may be a critical substrate for p210(bcr/abl)| a chimeric protein whose presence is associated with CML

A pseudogene has been identified on chromosome 22

TH Polyclonal Antibody, 50ul[BT-AP08988] Protein Analysis Members of the F-box proteinTyrosine 3 monooxygenase encoded by TH is involved in the conversion of tyrosine to dopamine. It is the rate limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have be associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.