BBS7 Rabbit Polyclonal Antibody, 50ul Palm Micro Centrifuges Defects in TRPS1 are a

Defects in TRPS1 are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III

Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways

The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme

and the ketone bodies acetoacetate

BBS7 Rabbit Polyclonal Antibody, 50ul Palm Micro Centrifuges Defects in TRPS1 are aThis gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin like BBS proteins (BBS6, BBS10, and BBS12) and CCT TRiC family chaperonins. Mutations in this gene are implicated in Bardet Biedl syndrome,