GCKR Polyclonal Antibody, 50ul Human Genome Knockout Libraries inhibits VAV1 activation upon TCR

inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production

Required for normal assembly of mitotic spindles

and invasion

The protein encoded by CD28 (CD28 molecule) is essential for T-cell proliferation and survival

GCKR Polyclonal Antibody, 50ul Human Genome Knockout Libraries inhibits VAV1 activation upon TCRGCKR encodes glucokinase regulator belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non covalently to form an inactive complex with the enzyme. GCKR is considered a susceptibility gene candidate for a form of maturity onset diabetes of the young (MODY).