DICER Polyclonal Antibody, 100ul RNA Synthesis In addition| a polymorphic repeat

In addition| a polymorphic repeat region is found in the C-terminus of the encoded protein

and has two modified domains that are thought to have lost their calcium binding capability

The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal

and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51

DICER Polyclonal Antibody, 100ul RNA Synthesis In addition| a polymorphic repeatThis gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.