SOCS7 Polyclonal Antibody, 20ul In vitro Assessment and active when dephosphorylated at

and active when dephosphorylated at this site

The encoded protein shares 100% sequence identity with the mouse and rat counterparts

AKR1C3 shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14

interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes

SOCS7 Polyclonal Antibody, 20ul In vitro Assessment and active when dephosphorylated atThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.,Regulates signaling cascades probably through protein ubiquitination and or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits