ITGA3 Rabbit Polyclonal Antibody, 50ul Miscellaneous Two alternative transcripts encoding different

Two alternative transcripts encoding different isoforms have been identified

The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases

The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein

It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates

ITGA3 Rabbit Polyclonal Antibody, 50ul Miscellaneous Two alternative transcripts encoding differentThe gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix