LRP3 Polyclonal Antibody, 20ul Dialysis HEY2 encodes a member of

HEY2 encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors

which bind microtubules

Alternative splicing results in multiple transcript variants encoding the same isoform

which sequester the cytosol and organelles for degradation by lysosomes

LRP3 Polyclonal Antibody, 20ul Dialysis HEY2 encodes a member ofNLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle Wells autoinflammatory syndromes. Mouse NLRP3 contains an N terminal Pyrin domain (aa 1 91) followed by a Nacht region (aa 216 532), and seven LRRs (aa 739 988). Within