FBX46 Rabbit Polyclonal Antibody, 50ul Enzymes The CDK8 subcomplex modulates Mediator-polymerase

The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates

This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component

RIN1 (Ras interaction/interference) was identified as a Ras-interacting protein in yeast

|tissue specificity:Isoform 1 is strongly expressed in the liver

FBX46 Rabbit Polyclonal Antibody, 50ul Enzymes The CDK8 subcomplex modulates Mediator-polymeraseMembers of the F box protein family such as FBXO46 are characterized by an approximately 40 amino acid F box motif. SCF complexes formed by SKP1 (MIM 601434) cullin (see CUL1; MIM 603134) and F box proteins act as protein ubiquitin ligases. F box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains (Jin et al. 2004