Rb(Phospho Ser811) Polyclonal Antibody, 100ul Cell Separation and Collection Multiple transcript variants encoding different

Multiple transcript variants encoding different isoforms have been found for CABLES1

The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA

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This protein shares strong similarity with DNA replication factor C (RFC)| and can form a complex with RFCs

Rb(Phospho Ser811) Polyclonal Antibody, 100ul Cell Separation and Collection Multiple transcript variants encoding differentThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.