MTHFR Monoclonal Antibody, 100ul Buffers & Solutions A gene knock out study

A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter

induction:Down-regulated in multiple tumors

The encoded protein also has phospholipase C activity

MTHFR Monoclonal Antibody, 100ul Buffers & Solutions A gene knock out studyThe protein encoded by this gene catalyzes the conversion of 5,10 methylenetetrahydrofolate to 5 methyltetrahydrofolate, a co substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.