Raf-1(Phospho Ser642) Polyclonal Antibody, 50ul sgRNA customized design The encoded protein is a

The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids

This gene product may act as an autocrine negative growth factor that regulates cell proliferation

Proteolysis also occurs by way of CUL-4 associating with Nedd-8

Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus

Raf-1(Phospho Ser642) Polyclonal Antibody, 50ul sgRNA customized design The encoded protein is aThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.