AP-1 Polyclonal Antibody, 50ul[BT-AP00488] Vacuum Aspirator Alternatively spliced transcript variants differing

Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene

and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators

The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3

Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080)| LYL1 (MIM 151440)| E2A (MIM 147141)| and SCL (MIM 187040)

AP-1 Polyclonal Antibody, 50ul[BT-AP00488] Vacuum Aspirator Alternatively spliced transcript variants differingJUN is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32 p31, a chromosomal region involved in both translocations and deletions in human malignancies.