SH2B3 Polyclonal Antibody, 100ul Lentiviral Packaging Guanine nucleotide exchange factor (GEF)

Guanine nucleotide exchange factor (GEF) for Rap1A

Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy

is not inhibited by warfarin

Alterations in this region have been associated with the Beckwith-Wiedemann syndrome

SH2B3 Polyclonal Antibody, 100ul Lentiviral Packaging Guanine nucleotide exchange factor (GEF)This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin dependent diabetes mellitus. Alternatively spliced