EKLF Polyclonal Antibody, 50ul Culture Plate Inserts Cullin proteins comprise a distinct

Cullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis

in that its endogenous ligand has not been identified

Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds

consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC

EKLF Polyclonal Antibody, 50ul Culture Plate Inserts Cullin proteins comprise a distinctKLF1 encodes a hematopoietic specific transcription factor that induces high level expression of adult beta globin and other erythroid genes. The zinc finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss of function mutations in this gene result in the dominant In(Lu) blood phenotype.