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LAT Polyclonal Antibody, 50ul[BT-AP04958] Nucleic Acid Isolation & Purification Mutations in NOTCH1 are associated
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LAT Polyclonal Antibody, 50ul[BT-AP04958] Nucleic Acid Isolation & Purification Mutations in NOTCH1 are associatedThe protein encoded by LAT (linker for activation of T cells) is phosphorylated by ZAP 70 Syk protein tyrosine kinases following activation of the T cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling
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