CLCN5 Polyclonal Antibody, 20ul Vortex Mixer Two transcript variants encoding distinct

Two transcript variants encoding distinct isoforms have been identified

beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster

RAF1 and IRS1 proteins

and also as a coactivator of NF-kappaB-mediated transcription

CLCN5 Polyclonal Antibody, 20ul Vortex Mixer Two transcript variants encoding distinctThis gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene.