Mouse Sterol Regulatory Element-binding Protein 1, SREBF1 ELISA Kit, 96T Funnels The paraplegin gene is responsible

The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia

Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1

Several antidepressants and antipsychotic drugs have a high affinity for this receptor

in conjunction with coreceptors TLR2 and TLR1

Mouse Sterol Regulatory Element-binding Protein 1, SREBF1 ELISA Kit, 96T Funnels The paraplegin gene is responsible[Sterol regulatory element binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed: 11782483, PubMed: 12855691, PubMed: 19244231). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol