Tensin-1 Polyclonal Antibody, 50ul Peptide Modification Alternative splicing generates multiple transcript

Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing

Overexpression of this gene has been observed in some cancer cells

has been correlated with DLX3 gene mutation

Interacts with the catalytic domain of HDAC9

Tensin-1 Polyclonal Antibody, 50ul Peptide Modification Alternative splicing generates multiple transcriptThe protein encoded by TNS1 (tensin 1)localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms.