PLZF Monoclonal Antibody, 50ul Measuring Instruments THOC5 localizes in the nucleus

THOC5 localizes in the nucleus and acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription

Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium

In response to cellular stress and proinflammatory cytokines

and it exhibits overall 46% amino acid identity to E2F1

PLZF Monoclonal Antibody, 50ul Measuring Instruments THOC5 localizes in the nucleusThis gene is a member of the Krueppel C2H2 type zinc finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL).