Rb(Phospho Ser612) Polyclonal Antibody, 20ul Deep Well Plates alternative products:Experimental confirmation may be

alternative products:Experimental confirmation may be lacking for some isoforms

This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits

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Rb(Phospho Ser612) Polyclonal Antibody, 20ul Deep Well Plates alternative products:Experimental confirmation may beThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.