Shc(Phospho-Ser239/240) Rabbit Polyclonal Antibody, 20ul Immunology Different family members and isoforms

Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions

Differentially expressed in 56% of thyroid

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the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL)

Shc(Phospho-Ser239/240) Rabbit Polyclonal Antibody, 20ul Immunology Different family members and isoformsThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms p52Shc and p46Shc link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation. Unlike