JIP4 Polyclonal Antibody, 50ul Hepatocytes Mutations affecting this gene are

Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3)

peptide synthesis

The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13

and may be involved in UV-induced signal transduction

JIP4 Polyclonal Antibody, 50ul Hepatocytes Mutations affecting this gene areThis gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen activated protein kinases and mediates c Jun terminal kinase signaling. This protein also binds to kinesin 1 and may be involved in microtubule based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.