INSI2 Polyclonal Antibody, 50ul Mini dry bath TFEB specifically recognizes and binds

TFEB specifically recognizes and binds regulatory sequences within the CLEAR box (GTCACGTGAC) of lysosomal and autophagy genes

and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12

the gene encoding VWA5A maps to human chromosome 11q24

Additional transcript variants have been described in publications but their full-length sequence has not been determined

INSI2 Polyclonal Antibody, 50ul Mini dry bath TFEB specifically recognizes and bindsThe protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.