ATR Polyclonal Antibody, 50ul Centrifuges The N-terminal DNA-binding domain confers

The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein

and increased levels of the encoded protein are associated with atherosclerotic lesions

Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins

The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2

ATR Polyclonal Antibody, 50ul Centrifuges The N-terminal DNA-binding domain confersThe protein encoded by ATR (ATR serine threonine kinase) belongs the PI3 PI4 kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1,