Rb(Phospho Ser795) Polyclonal Antibody, 100ul Cryogenic Vials CDH2 encodes a classical cadherin

CDH2 encodes a classical cadherin and member of the cadherin superfamily

Mutations in this gene are associated with susceptibility to obesity in humans

This gene has a pseudogene on chromosome 7

Mutations in CTSA are associated with galactosialidosis

Rb(Phospho Ser795) Polyclonal Antibody, 100ul Cryogenic Vials CDH2 encodes a classical cadherinThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.