VPS35 Polyclonal Antibody, 50ul Insect Expression Mutations in the alpha or

Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses

The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels

5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases

LRP11 is encoded by a gene located on human chromosome 6q25

VPS35 Polyclonal Antibody, 50ul Insect Expression Mutations in the alpha orVPS35 (VPS35, retromer complex component) belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and