Separase Polyclonal Antibody, 20ul Serological Pipets It is a heteromeric complex

It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes

particularly in cells of the myeloid and B-lymphoid lineages

suggesting its role in diverse biochemical activities related to signal transduction

Several transcript variants encoding different isoforms have been found for CFLAR

Separase Polyclonal Antibody, 20ul Serological Pipets It is a heteromeric complexStable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which