GRP3 Polyclonal Antibody, 100ul Deep Well Plates Mutations in this gene or

Mutations in this gene or its regulatory region cause hypobetalipoproteinemia| normotriglyceridemic hypobetalipoproteinemia| and hypercholesterolemia due to ligand-defective apoB| diseases affecting plasma cholesterol and apoB levels

Also detected in hepatoblastoma HepG2 cells

Two pseudogenes have been identified on chromosome 15

Defects in this gene are a cause of macular corneal dystrophy (MCD)

GRP3 Polyclonal Antibody, 100ul Deep Well Plates Mutations in this gene orMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP GDP regulated switches that cycle between inactive GDP and active GTP bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000