Ku-70 (Acetyl Lys331) Polyclonal Antibody, 100ul Centrifugal Filter 100 copies of pentanucleotide repeats

100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31

Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia

X-linked disorder occurring at a frequency of about 1 in 3

Extracellularly

Ku-70 (Acetyl Lys331) Polyclonal Antibody, 100ul Centrifugal Filter 100 copies of pentanucleotide repeatsThe p70 p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single stranded DNA dependent ATP dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with