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53BP1 Polyclonal Antibody, 50ul[BT-AP00042] In vitro Assessment in bladder and lung carcinomas

SKU: 2303368772

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PLN162.00 PLN189.00

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53BP1 Polyclonal Antibody, 50ul[BT-AP00042] In vitro Assessment in bladder and lung carcinomasThe p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA binding domain of wild type p53, but do not bind mutant p53. The central DNA binding domain of p53 is required for site specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site specific binding also suggests that 53BP1 and 53BP2 are

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Description

in bladder and lung carcinomas

cow and mouse

Also functions as a receptor for various alkaloids and psychoactive substances

This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus

53BP1 Polyclonal Antibody, 50ul[BT-AP00042] In vitro Assessment in bladder and lung carcinomasThe p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA binding domain of wild type p53, but do not bind mutant p53. The central DNA binding domain of p53 is required for site specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site specific binding also suggests that 53BP1 and 53BP2 are

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