FBXW2 Rabbit Polyclonal Antibody, 100ul Buffers & Solutions The encoded protein is required

The encoded protein is required for proper cornification in skin| with defects in this gene being associated with skin diseases

tissue specificity:Highly expressed in the pancreas

This gene encodes multiple protein isoforms that differ in their inhibitory activity

The gene is hypermethylated in many types of cancer

FBXW2 Rabbit Polyclonal Antibody, 100ul Buffers & Solutions The encoded protein is requiredF box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif the F box. Some F box proteins have been shown to be critical for the ubiquitin mediated degradation of cellular regulatory proteins. In fact F box proteins are one of the four subunits of ubiquitin protein ligases called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different