CIC Polyclonal Antibody, 50ul Electrophoresis & Labeling Mutations in this gene are

Mutations in this gene are associated with gastrointestinal stromal tumors| mast cell disease| acute myelogenous lukemia| and piebaldism

Contains 2 LRR (leucine-rich) repeats

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta

Alternative splicing of this gene generates 2 transcript variants

CIC Polyclonal Antibody, 50ul Electrophoresis & Labeling Mutations in this gene areThe protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG) box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C terminus. Studies suggest that the N terminal region of this protein interacts with Atxn1 (GeneID: 6310), to form a transcription repressor