Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler This gene encodes a dual-function

This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain

This gene is the cellular homolog of viral raf gene (v-raf)

This gene encodes a member of the PSCD family of proteins| which have an N-terminal coiled-coil motif| a central Sec7 domain| and a C-terminal pleckstrin homology (PH) domain

There is a microRNA gene located within the 5' exon of this gene

Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler This gene encodes a dual-functionThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.