CD58 Polyclonal Antibody, 50ul[BT-AP02361] Cell Labeling & Imaging Alternative splicing of the C-terminal

Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups

GPIb alpha chain provides the VWF binding site

Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols

It also interacts with multiple intracellular calcium release channels| and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor

CD58 Polyclonal Antibody, 50ul[BT-AP02361] Cell Labeling & Imaging Alternative splicing of the C-terminalCNNM2 encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in CNNM2 are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple