Rat Beta-Arrestin-2, ARRB2 ELISA Kit, 96T Cell Function Analysis Binds to and dephosphorylates 'Ser-15'

Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed: 15870257

Variations in GPR126 can affect a person's stature

Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed: 26711253)

which involves increased risk of cancers including malignant mesothelioma

Rat Beta-Arrestin-2, ARRB2 ELISA Kit, 96T Cell Function Analysis Binds to and dephosphorylates 'Ser-15'Functions in regulating agonist mediated G protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta arrestins bind to the GPRK phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta arrestins target