Rb(Phospho Ser608) Polyclonal Antibody, 100ul Protein Analysis Alternative splicing results in several

Alternative splicing results in several transcript variants encoding different isoforms

It can also form heterodimers with the related protein CEBP-delta

Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene

This receptor associates with guanine-nucleotide-binding (G) proteins

Rb(Phospho Ser608) Polyclonal Antibody, 100ul Protein Analysis Alternative splicing results in severalThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.