Histone H4 (Di Methyl Lys20) Polyclonal Antibody, 100ul Filtration Overexpression of this gene is

Overexpression of this gene is associated with glioblastoma

Multiple transcript variants encoding different isoforms have been found for this gene| but the biological validity of some variants has not been determined

The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus

Two of the protein's effects

Histone H4 (Di Methyl Lys20) Polyclonal Antibody, 100ul Filtration Overexpression of this gene isHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.