Presenilin 1 Polyclonal Antibody, 50ul Biomatrix By binding phosphotyrosines through its

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain

Alternatively spliced transcript variants encoding different isoforms have been described for GFRA4

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RPL28 encodes a ribosomal protein that is a component of the 60S subunit

Presenilin 1 Polyclonal Antibody, 50ul Biomatrix By binding phosphotyrosines through itsAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP.