SLP-76 Polyclonal Antibody, 50ul[BT-AP08367] Funnels This nuclear coactivator is proteolytically

This nuclear coactivator is proteolytically cleaved at one of the six possible sites

and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway

Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells

Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1

SLP-76 Polyclonal Antibody, 50ul[BT-AP08367] Funnels This nuclear coactivator is proteolyticallySLP 76 was originally identified as a substrate of the ZAP 70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP 76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2 terminus contains an acidic