Dok-2 Polyclonal Antibody, 100ul[BT-AP02697] Protein Expression The protein is a member

The protein is a member of the tripartite motif (TRIM) family

and regulate the activity of MAPK8/JNK1

|disease:Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86

A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis

Dok-2 Polyclonal Antibody, 100ul[BT-AP02697] Protein Expression The protein is a memberThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.